The GA-map™ platform technology utilizes common
and variable DNA sequences within the 16S rRNA gene of the bacteria to characterize
and identify the different bacteria.
A more detailed description of the technology can be found in the document “Technical
Description”, see link below.
In summary, what makes the GA-mapTM technology unique is a combination of a set
of proprietary, complimentary technologies:
|
I.
|
The GA-map ProbeToolTM software program uses special search mechanisms which makes
it possible to find a large set of combinations of DNA probes that can be used in
the test. Finding these combinations of probes for array generating is an essential
step in development of the GA-mapTM tests.
|
|
II.
|
A unique universal primer pair that can be used effectively to identify and amplify
bacterial DNA from virtually all bacteria present in the gut microflora.
|
|
III.
|
A novel method of labeling specific probes based on the presence of specific bacteria
in a mixed solution and sorting the labeled probes onto an array.
|
|
IV.
|
A database containing the information of profiles from the processed arrays, combined
to the health conditions of the individual.
|
The GA-map™ technology also includes a set of
other standard molecular biology tools that are optimized for this process.
Together, the GA-map™ technology makes it possible to generate profiles of a person’s
microbiota and correlate that profile to different health conditions. Two platforms
will be developed, one for the microflora in infants, and one for the adult microflora.
The composition of the gut microflora is markedly different in infants and adults.
The GA-map™ technology makes it possible, for
the first time, to effectively and on a routine basis analyze the composition of
the entire gut microflora, and correlate that composition or profile to various
health conditions. Although the importance of the gut microflora in the health of
individuals is widely recognized, no diagnostic tool has so far been available in
the market place.
Aditional reading:
- Company Profile (hyperlink)
- Techical Description (hyperlink)